Norovirus Capsid Assembly

Norovirus Capsid Assembly


During my PhD, under the guidance of Dr. Stephane Bressanelli and Dr. Yves Boulard,  I will try to better understand the Norovirus Capsid Assembly. My PhD lab is the newly created Institute for Integrative Biology of the Cell (I2BC). I will be located at the CEA (Commissariat à l’énergie atomique et aux énergies alternatives) Institute of Biology and Technology Saclay (iBiTec-S) since iBiTec-S houses part of the I2BC Department of Biochemistry, Biophysics and Structural Biology for the time being.

Aim of this project:

This project aims to better understand the Norovirus Capsid Assembly. The Norovirus Capsid is formed by 180 copies of one protein : VP1. It is a quite simple system, but in-vivo, the capsid is very efficient to assemble and disassemble itself. However, experimentally, the capsid transit from a non-stable state: while the capsid should have been destroyed, it manages to form properly.
My project is to use Molecular Dynamics methods to understand what happens during this transition state and how the norovirus capsid manage to assemble itself.

Applications:

Noroviruses are very resilient and biodisponible viruses. They are gastroenteritis viruses transmitted by the fecal-oral route, so they are transmitted by ingestion. Understanding their assembly mechanisms may allow development of new antivirals. Furthermore, their capsids can envelop more than RNA, so a better understanding of the Norovirus Capsid Assembly can be very useful for drug delivery.

This PhD Project is financed by the Ile-de-France under the Field of ​​Interest Major « Human Infectious Diseases: Mechanisms, Risks and societal impact » (Pathologies infectieuses humaines : mécanismes, risques et impact sociétal)

Logo-quadri-couleur

 

 

 


Talk and presentation

I present this thesis project at different places with different format :

  • CEA PhD Student days (Saclay, France – May 2015)
    Poster
  • Molecular Modelling workshop, Maison de la simulation (Saclay, France – May 2015)
    Oral communication
  • GGMM – Graphics Group and Molecular Modelling (Sète, France – May 2015)
    Poster
  • DSV PhD Students annual meeting (Porquerolles, France – October 2015)
    Oral communication + Poster
  • Research Group (GDR) on Membrane Protein (La-Londe-Les-Maures, France – April 2016)
    Oral communication
  • CEA PhD Student days (Saclay, France – May 2016)
    Poster
  • Doctoral School day – « My thesis in 180s » (Châtenay-Malabry, France – June 2016)
    Oral communication
  • International Society of Quantum Biology and Pharmacology (ISQBP) (Bergen, Norway – June 2016)
    Oral Communication

 

Pictures, animations and first results.

Only some videos are present since the results are not published yet.

  • This video is an update of the first « capsid description ». It was made for « My thesis in 180s – Doctoral School edition ».
  • This videos was created for a talk on the maison de la simulation of Saclay on a « image wall (8K – 3D – 4.3m on 2.3 : http://www.maisondelasimulation.fr/Visualisation.php). It aims to have a better view and comprehension of the Norovirsus Capsid.

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